Lingering or chronic pain affects every part of your life – from sleep, energy, mood, work, and relationships. If you’re living with pain, chances are you’ve tried several methods to greater or lesser success. Many people are now searching for natural, well-tolerated options to help ease discomfort without the side effects of long-term medication. There’s one standout ingredient in the world of pain management – palmitoylethanolamide (PEA) – sometimes also referred to as palmidrol.
PEA isn’t just a natural ingredient; it’s even naturally produced by the body in small amounts. Let’s take a closer look at PEA to understand how it works in the body and why it’s becoming a trusted option for individuals seeking relief from pain and inflammation.
What is PEA?
PEA, short for palmitoylethanolamide, belongs to a category of molecules called “endogenous fatty acid amides”, which help regulate pain and inflammation. The body makes PEA as part of its own defence system, particularly when body tissues are inflamed, irritated, or under stress. It works by supporting natural pathways that keep inflammation and nerve sensitivity under control.1,2
Although this fascinating compound can be made by the body, in times of increased inflammation or tissue damage, it’s unable to keep up with the demand – particularly when it comes to relieving pain. This is where a PEA supplement can provide extra support.
What does the research say about PEA for pain?
Research into PEA has shown promising results for people struggling with pain and inflammation dating all the way back to 1957 when it was first discovered.1
Here are the main outcomes of PEA research:1, 3
- Supports natural pain modulation pathways: PEA works with the body’s endocannabinoid system – a natural network in the body that helps to regulate pain, mood, sleep, and inflammation – and other systems that influence how pain is felt.
- Helps reduce inflammation: By calming overactive immune system responses, PEA may reduce pain and swelling.
- Manages nerve-related discomfort: Studies highlight its potential in easing neuropathic (nerve-related) pain, which is often hard to treat with standard medications and treatments.
Who can benefit from PEA?
Thanks to the wealth of supportive research behind PEA, people experiencing pain are reaching for PEA as a natural option for pain management – especially when dealing with issues:3,4
- Back pain
- Sciatica
- Osteoarthritis
- Neuropathic pain
- Chronic pelvic pain
For many, PEA offers an alternative that is well-tolerated, does not cause digestive upset or drowsiness, is non-addictive, and is safe for long-term use.
What makes a quality PEA supplement?
The quality of PEA supplements on the market can vary dramatically. If you’re interested in incorporating a PEA supplement into your pain and inflammation management, here are some things to look out for:
- High purity to ensure safety and efficacy.
- Micronised form, which essentially means the particles are very small, enhancing absorption and bioavailability.
- Trusted brands – reputable companies will provide information and transparency about their sourcing and quality standards.
A good PEA supplement for pain should give your body the best chance to absorb it and use it where it’s needed most.
Lifestyle considerations to improve results of PEA for pain relief
PEA works best as part of a broader, holistic approach to managing pain. If you’re struggling with pain and inflammation, consider pairing PEA with:
- An anti-inflammatory diet – antioxidant and omega-3 rich foods like oily fish, olive oil, nuts, seeds, dark leafy green vegetables, and vibrant fruits provide extra support for tissue repair.
- Gentle movement – low-impact activities like walking, yoga and swimming help maintain mobility and reduce stiffness.
- Stress reduction techniques – mind-body practices such as meditation, breath work, mindfulness, and having good boundaries around work and relationships can all contribute to easing muscle tension and reducing how intensely pain is perceived.
By combining PEA with healthy lifestyle habits, you’re giving your body a stronger foundation for long-term relief and resilience.
PEA offers a well-tolerated, evidence-backed way to support your body’s own pain-modulating and anti-inflammatory pathways. Choosing a high-quality, micronised PEA supplement and pairing it with considered diet and lifestyle strategies can help you feel more confident and supported.
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This article was written by Sophia Power, a Clinical Nutritionist.
References:
- Keppel-Hesselink JM, et al. (2013). Palmitoylethanolamide: A natural body-own anti-inflammatory agent, effective and safe against influenza and common cold. Int J Inflam, 2013:151028. https://pmc.ncbi.nlm.nih.gov/articles/PMC3771453/
- Keppel-Hesselink JM. (2013). Professor Rita Levi Montalcini on nerve growth factor, mast cells, and palmitoylethanolamide, an endogenous anti-inflammatory and analgesic compound. J Pain Relief, 2(1):1000114.
- Scuteri D, et al. (2022). Effects of palmitoylethanolamide (PEA) on nociceptive, musculoskeletal, and neuropathic pain: systematic review and meta-analysis of clinical evidence. Pharmaceutics, 14(8):1672. https://www.mdpi.com/1999-4923/14/8/1672
- Lang-Illievich K, et al. (2023). Palmitoylethanolamide in the treatment of chronic pain: A systematic review and meta-analysis of double-blind, randomised controlled trials. Nutrients, 15(6):1350. https://pmc.ncbi.nlm.nih.gov/articles/PMC10053226/#B13-nutrients-15-01350